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Influence of Age on the Dynamics of fMRI Activations during a Semantic Fluency Task

Abstract : Purpose : Age-related fMRI changes have not been extensively studied for language, whereas important adaptive mechanisms have been seen in other cognitive fields. This study examined age-related changes in fMRI activation during language tasks and, in particular, their dynamic course.Patients and methods fMRI was performed on 22 young and 21 old healthy right-handed subjects during a silent category word-generation task. Activation and dynamics of BOLD signals were studied separately during the first and second portions of each 30-s block.Results : Activation of the left frontal lobe was initially similar in young and old participants; however, it decreased after 30s in the old participants. On the other hand, additional areas were initially involved only in old subjects and especially in the default mode network.Conclusion :This study showed age-related differences in the dynamics of fMRI activation during a silent word-generation task, suggesting a different pattern of language function with aging.
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Submitted on : Tuesday, February 14, 2017 - 12:24:37 PM
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Christophe Destrieux, Caroline Hommet, Florence Domengie, Jean-Marc Boissy, Giovanni de Marco, et al.. Influence of Age on the Dynamics of fMRI Activations during a Semantic Fluency Task. Journal de Neuroradiologie / Journal of Neuroradiology, Elsevier Masson, 2012, 39 (3), pp.158-166. ⟨10.1016/j.neurad.2011.05.005⟩. ⟨hal-01467326⟩



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