Depression is one of the most prevalent disorders of our time. Depression remains nowadays in France and worldwide a major public health problem, still relatively difficult to treat, despite the important ongoing therapies currently available (anti-depressants, cognitive-behavioral therapy, etc). While antidepressant drug therapies are helpful for many depressed people, they also have many drawbacks and side effects. The maintenance in the longer term of treatment effects poses a particular problem, given the high probability of occurrence of depressive relapse, very difficult to avoid. However, research show that relapses are lower in psychotherapy. The positive psychology interventions offer some novel and promising perspectives for clinical practice. They prove indeed effective and complementary to other treatments of depression previously proposed and their effects seem to last longer. The aim of this article is to present positive psychology, and especially the new emerging positive psychotherapy and to underline its key features and benefits in the treatment of depression. The results of empirical studies and meta-analysis are promising; we thus encourage French clinicians to integrate positive psychotherapy and interventions promoted by Martin Seligman et al. to cultivate a lasting sense of well-being, which is a valuable resource for more effective and sustainable eradication of depression.